Total Syntheses of 11‐Acetoxy‐4‐deoxyasbestinin D, 4‐Deoxyasbestinin C, Asbestinin‐10, ‐20, ‐21 and ‐23
نویسندگان
چکیده
منابع مشابه
The total syntheses of basiliolide C, epi-basiliolide C, and protecting-group-free total syntheses of transtaganolides C and D.
The total syntheses of basiliolide C and previously unreported epi-basiliolide C are achieved by an Ireland-Claisen/Diels-Alder cascade. The development of a palladium catalyzed cross-coupling of methoxy alkynyl zinc reagents allows for the protecting-group-free syntheses of transtaganolides C and D. Syntheses of transtaganolides C and D are accomplished in a single operation to generate three ...
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The hasubanan akaloids are a large collection of natural products isolated from several medicinal herbs that are used in traditional Chinese medicine.[i] Members of this family share a common aza-[4.4.3]-propellane core, but vary substantially in the oxidation patterns of their peripheral structure. The least oxidized hasubanans are 8-demethoxyrunanine (1)[ii] and cepharamine (3);[iii] runanine...
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Plants belonging to the genus Thapsia have been acknowledged since antiquity for their remarkable medicinal properties. Until very recently, this has been attributed to their primary chemical component thapsigargin (Figure 1a), a widely utilized and structurally complex sesquiterpenoid metabolite known for its potent SERCA inhibition. Within the past decade, an additional group of structurally ...
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Several derivatives of 5-O-mycaminosyltylonolide substituted at C-23 have been prepared; these are 23-deoxy-23-C-methylene (3), 23-deoxy-23-C-(methoxycarbonylmethylene) (5), 23-deoxy-23-C-(ethoxycarbonylmethylene) (7), and 23-deoxy-23-C-(butoxycarbonylmethylene) (9), 23-deoxy-23-C-[(2E)-3-(ethoxycarbonyl)-2-propenylene] (11), and 23-deoxy-23-(dimethylaminoimino) (13), and 14-de(hydroxymethyl)-1...
متن کاملTotal syntheses of (-)-huperzine Q and (+)-lycopladines B and C.
Utilizing a late-stage enamine bromofunctionalization strategy, the twelve-step total synthesis of (-)-huperzine Q was accomplished. Furthermore, the first total syntheses of (+)-lycopladines B and C are described. An unprecedented X-ray crystal structure of an unusual epoxyamine intermediate is also reported, and the synthetic application of this intermediate in natural product synthesis is de...
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ژورنال
عنوان ژورنال: Chemistry – A European Journal
سال: 2020
ISSN: 0947-6539,1521-3765
DOI: 10.1002/chem.201904998